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In summary, adequate selenium supply effectively inhibits lipid peroxidation and ferroptosis in intestinal epithelial cells by upregulating GPX4 expression, thereby maintaining intestinal barrier integrity

You-Gui-Wan treatment significantly inhibited IL-6, TNF-, IL-4, IL-13, COX-2, arachidonate lipoxygenase (ALOX)-4, and HDC expression in a dose- and time-dependent manner and demonstrated significant inhibition of mast cell degranulation [165]

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Similarly, because baseline lipids were relatively normal in these healthy volunteers and lipid-lowering therapies were contraindicated in this study, the benefits of TLC-2716 when added to background therapies for hypertriglyceridemia (for example, fibrates and statins) in individuals with disease require confirmation