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We also sought to establish the mechanism of enzymatic inhibition by LCS3

Palmitate triggers inflammation through TLR4 not by acting as its direct agonist, but by altering cellular metabolism and membrane composition, thereby licensing TLR4-dependent inflammatory responses [36]

Mechanism of Action GHK-Cu chelates cupric ions (Cu2+) and delivers them to copper-dependent enzymes including lysyl oxidase, which is critical for collagen cross-linking and extracellular matrix stabilisation