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Several transcription factors such as activator protein (AP-1), nuclear factor kappa B (NF-B), and predominantly the nuclear factor erythroid 2related factor 2 (Nrf2) are involved in the induction of antioxidant enzymes

This study demonstrates a therapeutic effect of glutathione by oral administration in patients with NAFLD

Additionally, p53 regulates the biogenesis of iron-sulfur clusters and the copper chelator glutathione, which are two critical components of the cuproptotic pathway, suggesting that this tumor suppressor might play a role in cuproptosis