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Dynamic fuel switching in response to environmental stress is a fundamental adaptive strategy that allows organisms to efficiently match energy production to demand

High-fat diets have been shown to cause metabolic inflammation throughout the tissue, elevating the levels of endotoxins, circulating free fatty acids, and inflammatory mediators, resulting in low-grade systemic inflammation and distressed homeostasis in many tissues 98

A group of fats called long-chain fatty acids must be attached to a substance known as carnitine to enter mitochondria

For instance, the trial conducted by Vukovich didnt show an increase in the muscle l-carnitine content explaining possibly the lack of benefit [43]