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Due to the existence of the conjugated system of C = C bonds and carbonyl groups, 4-HNE can provide partial positive charge to the carbon at position three and become efficient electrophiles, allowing it to react with essential biological molecules, including proteins and DNA (107109)

Transcriptionally, NF-B is a primary driver that induces NLRP3 expression through Toll-like receptor (TLR) signaling in response to ligands such as lipopolysaccharides (LPS), while STAT proteins further modulate transcription

It works with the bodys natural repair mechanisms instead of against them, offering a more balanced and sustainable approach to inflammation control

During this period, patients are advised not to use paracetamol as a treatment for any condition