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The lack of regulation by adenylylation could have provided the flexibility for parasite GS to function in all the life cycle stages irrespective of its energy metabolism being supported by glycolysis or oxidative phosphorylation

These modifications may include the Vssc mutation, insensitivity of synaptic acetylcholinesterase (AChE1) and mutation in the GABA receptor [56]

This apoptosis is primarily mediated through mitochondrial damage, although interesting, ROS generated by pyocyanin do not appear to play a significant role in this process (145)