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Sidharth Sonthalia stated in 2018: The unbridled use of parenteral formulation seems unjustified. Understanding glutathione IV dosing requires recognizing that safer, more cost-effective alternatives exist through oral and topical formulations with better long-term outcomes.

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Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation