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5,6 Furthermore, measurements of metabolites such as methylmalonic acid and homocysteine have been shown to be more sensitive in the diagnosis of vitamin B 12 deficiency than measurement of serum B 12 levels alone

7 These reductions were not accompanied by systemic immunosuppression markers, suggesting local rather than systemic anti-inflammatory activity a profile more consistent with tissue-level NF-B pathway modulation than with global glucocorticoid-type immunosuppression