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Evidence showed that fatty acid synthesis is markedly upregulated during differentiation of primary human monocytes, and its inhibition reduces macrophage phagocytosis, which can be fully rescued by supplementation with a fatty acid-CoA mixture (34)

(227) demonstrated that increased ROS in the cytoplasm activate transmembrane protein 16F (TMEM16F), leading to outward chloride ion flux and disruption of membrane phospholipids