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Treatment with divalent cations (e.g., iron and copper) leads to the formation of -synuclein oligomers in the presence of DOPAL (dopamine aldehyde or 3,4-Dihydroxyphenylacetaldehyde), which is a neurotoxic product of dopamine metabolization

It does this by neutralizing free radicals and reducing oxidative stress

Tocopherols and tocotrienols in common and emerging dietary sources: occurrence, applications, and health benefits

In addition, insulin administration is known to result in increased GST gene expression through the PI3K/AKT/mTOR pathway and reduced intracellular oxidative stress, while glucagon decreases such gene expression