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Zuzak E, Horecka A, Kieczykowska M, Dudek A, Musik I, Kurzepa J, Kurzepa J

Clinical Cancer Research, 19 (3), 560570

The study showed that rutin can target the Cys 151 of Keap1, and form an adduct with Keap1 which results in Nrf2 activation and upregulation of glutamate cysteine ligase, a glutathione biosynthesis rate-limiting enzyme which plays an important role in the endogenous antioxidant system (Sthijns et al., 2017)