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A true genetic polymorphism is defined as the occurrence of a variant allele of a gene at a population frequency of 1%, resulting in altered expression or functional activity of the gene product, or both

doi: 10.1523/JNEUROSCI.0512-16.2016 184 NumataS.YeT.HydeT

Consequences of Glutathione Deficiency Low glutathione levels can lead to: Increased oxidative stress and cellular damage: Without adequate glutathione, free radicals accumulate and damage DNA, proteins, and lipids

It is noteworthy that the disulfide linkage between homocysteine and the cysteine-rich domain of annexin II is responsible for the homocysteine-specific inhibition of t-PA binding to annexin at the cell surface (Hajjar et al, 1998)