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To determine whether SLC25A39 transport function is essential for GSH import into mitochondria, we generated a homology model of SLC25A39 based on that of the bovine ADP/ATP transporter 19 that facilitated the identification of three potential substrate binding residues, K329, M133 and D226 (Fig

Left: Many cancer cells generate large amounts of ROS and RNS but also have elevated antioxidant defenses, largely through upregulation of the Trx and GSH systems