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Under the therapeutic concentrations, approximately 60%90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%15%) being metabolized by the cytochrome P450 pathway (CYP450) ( via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Figure 1)

Patient, donor and harvest characteristics Variable N=10 Age, median(range in years) 11 (2-15) Gender, n Male, 6 Female, 4 Diagnosis, n ALL IICR,1 ALL III CR, 1 AML I CR,3 AML II CR, 2 NB,1 NHL, 1 AHL, 1 Conditioning regimen, n Flu 150mg/m2 + Treo 36g/m2+Mel140 mg/m2, 1 Flu 150mg/m2 + ARA-C 8000 mg/m2+Mel 180 mg/m2, 1 FLAME- Flu 150 mg/m2+CCNU 300mg/m2(p.o.)+ ARA- C 4000 mg/m2+ VP-16 1000 mg/m2+Mel 140 mg/m2,8 Donor, n Father, 5 Mother, 3 Sibling,2 Stem cells source Peripheral blood, 7 Bone marrow,3 Results: 1/10 pts died before engraftment at day +20 (fulminant Ps

doi: 10.5740/jaoacint.18-0418

Weir, H