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Long-term safety data are lacking, and as with other peptides affecting tissue remodeling, theoretical concerns about promoting abnormal cell growth exist

Although there are several electrophiles available for labeling nucleophilic lysine such as activated esters 39 , sulfonyl chlorides 40 or isothiocyanates 41 , these are limited due to cross-reactivity with other reactive amino acids on proteins

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Using the Adult Treatment Panel (ATP III) diagnostic criteria, a prevalence of 26.6% was estimated and according to the WHO criteria the prevalence was 13.61%