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Parkinsons disease PD is characterized by degeneration of dopaminergic neurons, affecting millions of people worldwide and ranking as the second most common condition of its kind after Alzheimers disease 32

Puerarin-loaded PLGA were orally administered to Sprague-Dawley rats, where pharmacokinetic analysis showed a 10.52-fold increase in plasma bioavailability and a 6.46-fold increase in brain puerarin accumulation compared to oral administration of free puerarin

The primary purpose of this visit was to assess compliance and record adverse events

Concomitantly, other cytokines such as IL-1 and , IL-10, IL-6, and others exhibited lower concentrations in Mda5 -/- bone marrow serum, while other cytokines like TNF and IFN showed no differences (Fig