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IVDD is defined by rapid extracellular matrix breakdown, nucleus pulposus cell loss, and an inflammatory response

The prognosis is difficult to predict, as few patients are known, but seems to vary significantly between different patients

Therefore, most (78%) of the clonal drivers identified by analysis of the ratio of protein altering to silent mutations from sequencing human or mouse esophagus altered cell fitness in this CRISPRCas9 screen (Fig

Peer review Peer review information Nature Reviews Drug Discovery thanks Robert Thorne, Richard Keep and the other, anonymous, reviewer(s) for their contribution to the peer review of this work