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Additionally, systematic reviews indicate that naringenin, in combination with other polyphenols, improves metabolic parameters and decreases liver fat content in affected individuals [237244]

Monitoring Side Effects Prior to starting thiopurine therapy, a clinical assessment should be performed to ascertain whether patients are at risk of developing opportunistic infection or adverse drug reactions

Genetic studies reinforce this connection: mutations in ferroptosis-associated genes, such as DJ-1 (a negative regulator of ferroptosis linked to autosomal recessive PD) and ACSL4, have been implicated in PD susceptibility [132]