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Metabolic regulation of PDK The activity of PDKs is finely regulated by diverse intracellular metabolites, enabling them to orchestrate pyruvate flux into the TCA cycle and thereby influence cisplatin sensitivity

doi:10.1210/jc.2015-3754 PubMed | Crossref | Google Scholar Hurley-Kim K, Vu CH, Dao NM, et al

Sirtuin 5 alleviates liver ischemia/reperfusion injury by regulating mitochondrial succinylation and oxidative stress

However, when the vitreous gel slowly liquefies with age, the lens is gradually exposed to slightly ever-increasing amounts of molecular oxygen, and slowly progressive nuclear sclerosis ensues