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Back in the 1950s, scientists speculated that high doses of vitamin B12 might trigger breakouts

Neurological changes A lack of vitamin B12 can cause neurological problems, which affect your nervous system, such as: vision problems memory loss pins and needles loss of physical co-ordination (ataxia), which can affect your whole body and cause difficulty speaking or walking damage to parts of the nervous system (peripheral neuropathy), particularly in the legs If neurological problems do develop, they can sometimes be irreversible

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Piezo1 is also associated with the tumor microenvironment (Zhou et al., 2020)