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While the UPS is responsible for the rapid degradation of short-lived and misfolded proteins, autophagy handles long-lived proteins, protein aggregates, and damaged organelles

IGF-IR promotes tumor growth, anoikis evasion, and metastasis PI3K is a classical lipid kinase that catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P 3 ) [44]