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The copolymer was folic acid-coated PEG-PDS, and the loaded micelle exhibited high cytotoxicity towards a GSH-treated human Henrietta Lacks (HeLa) strain cancer cell line as well as stable, prolonged blood circulation and excellent tumor accumulation [65]

LC-MS/MS data quality evaluation and statistical analysis were done using software Perseus v.1.6.15.0 Untargeted metabolomics Cells were seeded in a 12-well plate with an optimized cell confluency ( 1500 quantifiable peaks of putatively annotated metabolites