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This makes it more accessible compared to other peptides that require injections

Recent advances have explored PEGylated lipid nanoparticles, which combine the benefits of stealth properties (to evade immune clearance) and controlled delivery

In briefing documents submitted to the FDA's Pharmacy Compounding Advisory Committee, some experts warned that the peptides are "extremely sensitive" to formulation and environmental conditions and lack evidence that they treat the conditions claimed

Cluster three (blue) emphasizes PSCI risk factors, including keywords such as dementia, Alzheimer's disease, risk factor, vascular dementia, TIA (transient ischemic attack), brain infarction, MRI, small vessel disease, vascular cognitive impairment, and age. The smallest cluster (yellow) primarily relates to assessment and diagnosis, covering terms such as MMSE, MoCA (Montreal Cognitive Assessment), validity, diagnosis, frequency, reliability, validation, neurological disorders, neuropsychology, and questionnaire. To explore the research topics that have captured attention from 2010 to early 2023, we used CiteSpace in conjunction with the alluvial generator to successfully plot the alluvial flow graph of PSCI's academic keywords (Figure 8C)