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Future studies should incorporate human iPS cell-derived astrocyte models, precision delivery platforms and multimodal biomarkers to bridge these gaps and accelerate astrocyte-based therapies from mechanistic insight to clinical practice

Oral citicoline (four cycles of 500 mg/day for four months followed by a two-month washout period) was also found to significantly reduce the rate of visual field loss and the level of intraocular pressure in 41 patients with progressive glaucoma (89)

EBioMedicine 2 , 17351750 (2015)

Key Points The basic pattern of genomic DNA methylation is established at the time of embryo implantation through a wave of de novo methylation, but CpG islands are protected through a mechanism that involves the recognition of histone H3 lysine 4 methylation