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Based on the above assumptions, we propose a novel potential intervention strategy: targeting GPX3 and MYC by modulating specific gut microbiota metabolites (such as Diosgenin and DIF-3), thus achieving multi-level regulation of the RA pathological process

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Infertility and miscarriage : Untreated coeliac disease may contribute to reproductive issues, such as infertility, recurrent miscarriages, and low birth weight babies