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The net effect of the breakdown of this intra-islet homeostasis results in the dysregulation of insulin secretion, leading to significant hypoglycemia ( Somatostatin receptor distribution A large number of studies have sought to characterize the expression of SSTs in human pancreatic tissues, but cataloging the differences between them is beyond the scope of this review ( Recent work from islets isolated from CHI patients undergoing pancreatectomy for focal, diffuse, or anomalous CHI ( Somatostatin receptor ligand use in congenital hyperinsulinism Somatostatin treatment was first described in a child with CHI after 80% pancreatectomy ( via a pump in a 6-month old infant with insulin excess ( Short acting SRL treatment The strategy to use octreotide subcutaneous injections administered every 4 to 8 hours ( Long acting SRL treatment Long acting SRLs have been tried in small groups of patients with reported success ( Side effects of SRL treatment Both octreotide and lanreotide possess similar SST receptor pharmacological profiles (primarily SST2 agonists) ( Supplementary Table 1 ) and are therefore expected to have a similar range of both therapeutic and adverse effects