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ICOSL / or B cell-specific ICOSL / mice have markedly inhibited development of proteoglycan-induced arthritis, with notable reductions in T FH and GC B cells, IL-21 production, and proteoglycan-specific IgG antibody responses (113)

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Additionally, findings revealed that grape seed extract inhibited the phosphorylation of proteins such as ERK, JNK, and P38 in human epidermal keratinocytes subjected to UVB irradiation, suggesting its ability to suppress the MAPK signaling pathway and consequently reduce UVB-induced collagen degradation (60, 76)

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