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81,143,144,145 Even though the overexpression of enzymes involved in both the synthesis and breakdown of H 2 S has thus far only been reported for colorectal cancer, 134 it can be envisaged that overexpression of both enzymatic pathways might be a common trait for any cancer type where H 2 S production is increased, as excess H 2 S can become toxic even for the most robust cancer cells (see below)

[DOI] [PubMed] [Google Scholar] 22.Vogler M, Hamali HA, Sun XM, Bampton ET, Dinsdale D, Snowden RT, Dyer MJ, Goodall AH, Cohen GM

Collectively, this multidimensional enzymeproductcelltissue framework holds strong potential as a reference for mechanistic studies and precision therapies

The filtrate is evaporated and the glutathione is purified by recrystallization from 50% ethanol