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Song JJ, Tian WJ, Kwok LY, et al

The foundational mechanism underpinning these effects is the production of neuroactive metabolites by gut bacteria, which bear structural and functional resemblance to host-derived neurochemicals (448)

In general, hydrophilic amino acids contribute to the formation of a hydrophobic pocket in the H-site adjacent to the GSH-binding site (Figure 3B&C) [80, 85]