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This state, characterized by an imbalance between ROS production and elimination by the antioxidant system in favor of ROS formation, is termed oxidative stress (Sies 2023)

Correspondingly, instead of mainly functioning as an energy provider, the mitochondria of ECs are mostly involved in nitric oxide (NO) production, intracellular signaling and the senescence and apoptosis of endothelial cells, all of which are associated with atherosclerosis development

Relative risk estimates follow a continuous exposureresponse relationship, derived from meta-analyses of epidemiological studies

LiuNYuZXunYShuPYueYYuanSet alAmyloid-25-35 upregulates endogenous neuroprotectant neuroglobin via NFB activation in vitro