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[DOI] [PubMed] [Google Scholar] 262.Kouroedov A, Eto M, Joch H, Volpe M, Lscher TF, Cosentino F

doi: 10.1038/349431a0 33 DukanSFarewellABallesterosMTaddeiFRadmanMNystrmT

GALC dysfunction results in elevated levels of cytotoxic D -galactosylsphingosine in neural tissues, which leads to extensive degeneration of oligodendrocytes and Schwann cells, followed by destructive demyelination