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A.1997High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinsons disease.2212-3, (January 1997),202204,0304-3940 67

In an arthritis mouse model, low doses of recombinant IL-37 were able to inhibit 51.7% of arthritic inflammation, promote IL-1R expression, and reduce the synovial levels of IL-1, IL-6, TNF-, CXCL1, CXCR3, macrophage inflammatory protein 1-alpha (MIP-1), IL-1, and myeloperoxidase (MPO), thereby decreasing the recruitment of neutrophils to the joints ( 5.6 Cytokine redundancy and therapeutic strategies targeting IL-1RAcP Cytokine redundancy refers to the phenomenon where distinct cytokines bind to identical or structurally similar receptors, activating overlapping signaling pathways to elicit analogous biological functions

[DOI] [PubMed] 69.Jong C.J., Ito T., Schaffer S.W

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