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Fujimoto et al

In order to gain insights into biological pathways associated with increasing emphysema severity within a patient and explore computational strategies for identifying COPD therapeutics, we obtained paired samples from eight regions at regular intervals between the apex and base of each explanted lung from six patients with severe COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage IV) and two donor lungs

Recent CV outcome trials (CVOTs) have identified newer therapeutic agents with CV benefits, such as sodium-glucose cotransporter-2 (SGLT-2) inhibitors reducing hospitalization for HF and glucagon-like peptide-1 (GLP-1) receptor agonists reducing major adverse CV events (MACE), albeit with inconsistent effects on HF outcomes (70)

Sun Z, Wu J, Bi Q, Wang W