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SN38-glu-Mal accumulated more at the tumor site than irinotecan, with its concentration in tumor tissue 30 times higher after 48 h

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The activated iodine binds to tyrosine residues on thyroglobulin molecules under the action of TPO to produce monoiodotyrosine (MIT) and diiodotyrosine (DIT), which are subsequently coupled to produce T3 or T4 ( Figure 1 )