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Heffernan 2001b This metabolic selectivity has a dosage implication: once the beta-3 receptors in adipose tissue are adequately occupied, additional peptide does not proportionally increase the lipolytic signal

While direct evidence linking NNMT activity to hypertension is currently lacking, numerous studies have established a strong association between NNMT activity and various metabolic disorders, including cardiovascular diseases (Li et al., 2006