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Gender-related differences are small (2%) (58)

Studies associate this state with lower mtDNA copy number and higher levels of mtDNA mutations in CD4+ T cells (116, 117), suggesting an underlying mitochondrial incapacity to fuel the energy-demanding processes of cell proliferation and survival

doi: 10.1038/s41575-020-0271-2 241 StavropoulouE.KantartziK.TsigalouC.KonstantinidisT.RomanidouG.VoidarouC.et al

Higher amounts of TRX and GRX were found to protect cells from the reactive dopamine metabolite 6-OHDA-benzenediol, which is critical for neuronal survival in dopamine-induced cell death (Arodin et al., 2014)