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Optimising preclinical research and future directions for the clinical utility of MET inhibitors in chemoresistant disease The modest clinical benefit of MET/HGF inhibitors in combination with chemotherapy in clinical trials necessitates review of why the preclinical evidence for these compounds is not translating into clinical practice

The four-pathway approach activates mechanisms that single or dual agonists cannot reach, potentially overcoming resistance that develops with prolonged use of less comprehensive compounds

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Human clinical trials establishing these effects have not been completed and conclusions about efficacy in humans should not be drawn from this data alone