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We are also deeply grateful to Dr

10.3390/ijms25179244 Int J Mol Sci

Metabolites were annotated using the MassHunter software (Agilent) according to the National Institute of Standards and Technology (NIST, Gaithersburg, USA) library and external standards listed above

Curcumin was given either alone (orally at 2, 4, 6, 8, or 12 g/day in two divided doses) or in combination with bioperine (10 mg in two divided doses) for 12 weeks