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Brain imaging studies show that changes are going on with multiple neurotransmitters, including the cholinergic, noradrenergic, and dopaminergic circuits.[ref] REM sleep behavior disorder is strongly linked to eventually developing Parkinsons disease

Glutathione is one of the body's most important antioxidants, playing a central role in cellular protection, detoxification, and immune defense

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In addition, caspase 8 can cleave Bid (Bcl-2 interacting domain), a pro-apoptotic factor that, once cleaved, activates the intrinsic pathway of apoptosis by interaction with pro-apoptotic factors Bak and Bax