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In rats, dogs, and swinethe three species where both compound classes have been extensively characterizedcombined administration produces peak GH levels 2- to 5-fold higher than predicted from additive effects

Patients undergo cyclophosphamide therapy every three to four weeks, with the frequency of administration determined by the physician and based on the severity of the patients illness

GHRP-2 has also been studied for its ability to stimulate GH in patients with mutated GHRH receptors demonstrating that GHSR-1a provides an independent rescue pathway for GH release even when the GHRH axis is compromised (Maheshwari et al., 2002)