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doi: 10.1016/j.cmet.2004.12.003 71 KelleyD

Despite doubling the amount of ET administered between low and high dose (35 to 70 mg/kg/day), no significant differences in ET accumulation were observed, except in the liver and eye

Yes, I have done it several times before

Methods: A systematic literature search of Embase, PubMed, and Web of Science databases was performed from inception to October 2022 in accordance with PRISMA guidelines