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Description

A glutation koncentrcija termszetes mdon a kor elrehaladtval is folyamatosan cskken, emellett egyes kutatsok szerint a glutationszintek nemenknt is eltrhetnek, amelynek valsznleg hormonlis okai is lehetnek

The method of claim 29, comprising identifying an antigen binding site variant by its decreased antigen binding affinity or antigen binding specificity as compared to the affinity or specificity of the first antigen binding site to the antigen

One mechanism is mediated by perforin deficiency, similar as above described in CD8 + CTLs

We suggest that integration of targeting tumor metabolism with immunotherapy could be a rational approach to modulate the TME and improve therapeutic efficacy of MM