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Given both the extent of disability caused by age-related cataract and its costs, $5 to $6 billion per year 26 (Congressional Testimony of S.J

Everolimus pharmacokinetics and its exposuretoxicity relationship in patients with thyroid cancer

It is characterized by a quickly decrease in hemoglobin concentration, striking clinical features, and occasionally hemoglobinuria (dark urine)

Therefore, it is important to investigate i) the impact of CKD on the heart in larger animals and ii) in a more clinically relevant scenario, where other (metabolic) comorbidities, such as DM, co-exist (i.e., the concept of a second hit)