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Many patients choose the compounded route specifically because the predictable cash price is lower than the branded copay over a year of treatment

they create what researchers refer to as a massive immunological "energy sink." Because the immune cells (particularly T-cells and memory lymphocytes) are trapped in a state of severe oxidative stress, they are forced to consume excessive amounts of the host's energy just to survive the ongoing cellular damage and attempt repairs

Fukui M, Choi HJ, Zhu BT

In one the age was proposed as an independent predictor only in women, while the other study showed age as a risk factor for MASLD only in premenopausal women, but not in menopausal women [90]