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Description

Many of these associations occur within the spectrum of autoimmune polyendocrine syndromes (APS)

Symptoms may range from mild skin irritation to more severe symptoms like difficulty breathing and anaphylaxis

In contrast, in macrophage-like cells, synthetic ICA derivatives (at concentrations of 10.821.6 M) elicit a distinct response: within 4 hours of exposure, they activate endosomal TLR3 and surface TLR4 (164), triggering cascades of type I interferons (e.g., IFNB1) and proinflammatory cytokines (e.g., IL6, IL12A/B) that amplify innate antiviral immunityunderscoring ICAs context-dependent functional plasticity