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Similarly, in a systems pharmacology analysis of Banxiabaizhutianma decoction, Pinelliae Rhizoma (stigmasterol) and Gastrodiae Rhizoma (gastrodin) were confirmed as the monarch TCMs for treating phlegm-dampness hypertension [211]

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ROCK regulates actin cytoskeleton reorganization by phosphorylating LIM kinase and cofilin, leading to increased endothelial cell gaps, elevated vascular permeability, and infiltration of inflammatory factors, thereby exacerbating endothelial damage [36]