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Cancer 8 , e001089 (2020)

KY19382 completed preclinical trials and was in formulation development as of the last public updates

In contrast to acute tolerance, chronic tolerance can be mediated through either pharmacokinetic or pharmacodynamic mechanisms, with an end result of a long-term decrease in drug response in the face of constant systemic exposure

Pharmacological Interventions for Alzheimer's Disease Current pharmacological interventions for AD primarily focus on symptom management rather than disease modification

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