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Description

En cultivos de adipocitos, la inhibicin de NNMT con este compuesto se ha asociado con incremento de NAD+ intracelular, activacin de AMPK y aumento de la beta-oxidacin de lpidos, reduciendo el tamao de las gotas lipdicas en modelos celulares

This is accompanied by an increase in lipid peroxidationa hallmark of ferroptosiswhich can trigger oxidative damage, inflammation, and placental dysfunction, potentially leading to preeclampsia and GDM