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Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training

Iron is probably one of the most important metals sustaining critical physiological processes, but also with the potential to cause neurotoxicity when in excess

The activation of NRF2 by this mechanism enhances the transcription of genes involved in antioxidant defense and cystine/glutamate exchange, particularly those coding for components of the xCT antiporter (such as SLC7A11), which imports cystine in exchange for glutamate