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The IADVL 2017 Position on Skin Lightening Agents takes a careful line on intravenous glutathione: the FDA has not approved it for cosmetic indications, the dermatology evidence base shows modest tyrosinase-inhibition effect with topical pigment control doing most of the visible work, and the off-label cosmetic use sits firmly outside a curative claim

Whether glutathione is safe to use while pregnant or nursing is unknown due to a lack of trustworthy information

These symptoms may suggest OIH only if there is no evidence of underlying disease progression, opioid tolerance, opioid withdrawal, or addictive behavior

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